We develop a personalized real time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs. Heterogeneity of the patients population is captured via a hierarchical latent class model. The proposed algorithm aims to discover the number of latent classes in the patients population, and train a mixture of Gaussian Process (GP) experts, where each expert models the physiological data streams associated with a specific class. Self-taught transfer learning is used to transfer the knowledge of latent classes learned from the domain of clinically stable patients to the domain of clinically deteriorating patients. For new patients, the posterior beliefs of all GP experts about the patient's clinical status given her physiological data stream are computed, and a personalized risk score is evaluated as a weighted average of those beliefs, where the weights are learned from the patient's hospital admission information. Experiments on a heterogeneous cohort of 6,313 patients admitted to Ronald Regan UCLA medical center show that our risk score outperforms the currently deployed risk scores, such as MEWS and Rothman scores.

Multiple concurrent physiological streams generated by various medical devices play important roles in patient condition assessment. However, these physiological streams needto be analyzed together and output in real-time for preciseand timely controlling and management, which poses a non-trivial challenge to existing methods. This paper presents ourresearch on real-time assessing based on this kind of data.To address this problem, we first extract sketches from original data with the help of adaptive sampling and wave splittingalgorithm, then define scalable operators on sketches and propose MUNCA (MUlti-dimensional Nearest Center Analysis)to combine these multiple concurrent data together for anal-ysis. Experiments on real data demonstrate the effectiveness and efficiency of the proposed method.